For those of you who don't know, Amy Lee is the singer of Evanescence. Cartoon Cartoon Friday is the night on Cartoon Network where a fat white man and ugly black girl dance around with a bunch of 8 year olds and watch the latest Powerpuff Girls cartoon.
Now, you put those two together, and there is a bit of amusement to be had, especially since the commercial did appear to have Amy with a guitar.