Clemson is in the north-western tip area of South Carolina. It's about a four hour drive from Charleston (pretty good and in between, it sounds like). There's another place in Spartanburg SC (where I'm from, about an hour east of Clemson) you would fit in, but the turnout is pretty thin. Still,, it would be better than nothing, if you needed a gig on the way down or the way back up.
http://guitarbar.net/ Ask for Marc.