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I've always wondered if something like that could happen to humanity.
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Probably not, considering that we have the ability to create technology. We have basically eliminated natural selection from the human equation over the millennia, so "bad mutations" aren't all that inconcievable, especially with future advances in genetics. A small group of humans could even survive a planet-wide catastrophe (except something like the Sun going supernova or the planet cracking in half) with the right technology.