[FS]

Two villains could work, and I think is going to be inevitable. They just have to think it through. The Riddler and Two-Face had nothing in common, and Poison Ivy and Mr. Freeze even less. They could either pick a few guys who've actually worked together against Spider-Man in the comics, or who don't work together and just fight Spider-Man on their own. Like the Rocket Racer and Big Wheel.