I drive quite long distances every week so I listen to various podcasts to help stave off bordom, my favourites include:
Diggnation (Discussion of articles from the site digg.com - quite funny and not all that techie although there are definalty nerdy undertones to most articles)
PC Gamer Podcast (Gaming news and interviews, can be funny but is mostly just a bit interesting)
Extreme Tech (Very techie indeed, mostly computer hardware and electronics discussion)
Cinecast (Film reviews and top 10s and alike. The presenters are hardcore film geeks but it still manages to be entertaining most of the time)
Do you listen to anything? If so what are your favouries?