grav gun in HL2.
barry's magnum in RE1.
the broken butterfly in RE4.
blades of chaos in God of War.
the medic's syringe gun and pyro's flamethrower in Team Fortress 2.
rapid-spread in contra.
and, of course, the grand daddy of them all: the pistol in halo 1.
EDIT: I only read page 1 before posting. Not tryin to cop asparagus up there
