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it definitely has some negative effects on the person's ability to reason and socialize.
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Having had some experience with sufferers I found one of the main problems to be their inability to really understand when I was making a joke or being sarcastic, which led to quite a bit of awkwardness and such.
It's almost like assburgers sufferers have evolved to better fit in on the internet; they don't understand humour or sarcasm and they spend a great deal of time telling you about things like Anime and really shitty video games.