Boom Blox = virtual Jenga.
That said, I'm looking forward to The Conduit, Deadly Creatures, and Disaster: Day of Crisis.
Right now, I'm enjoying Wario Land: Shake it. Not that it's revolutionary or anything, but in this day and age a good sidescroller is a welcomed treat.
Hell, Mario Galaxy, Zack & Wiki, and Metroid Prime 3 are sure to become sought-after gems if the Wii ever goes belly-up.