Which issue?

[KevinTheOmnivore]

I want to try something slightly new here. A little background, my interest of political study focuses mainly on political parties, their alignments throughout history, etc.

Some theorists, such as James Sundquist, have argued that partys realign, and ideological loyalties shift, when one big issue is ignored by the two main parties, thus generally and historically leading to high third-party activity, or a swelling of reform from within one or even both of the parties.

So my question is this: Do any of you see such an issue troubling the two-party system in the near future??? Is there any issue that you feel both parties have neglected, to the point that it could cause a major shift in the system somewhere down the road....?

I'd love to hear everyone's thoughts.