Most annoying character, ever.

[BurntToShreds]

Atlas from BioShock.
"NUTHIN LOIK A FIST FULLOUGH LOIGHTNIN', IS THERE?"

"MOIRA!!! PATRICK!!"

"WEEL FOIND ROYIN, AND TAYR 'IS BLEEDIN' HERT OUT!!"

Also, every female fighting game character ever. Taki, Ivy, all the DOA girls, and especially Chun-Li. Her character designer likes thick girls. It said so in a cover story about Street fighter IV.

Poison doesn't count, you'd know why if you've heard "her" backstory >_>

And finally, Death from Castlevania. Those sickles flying through the air get me nearly every time.