I guess it depends on the comedian who wants to use it. They wouldn't tell me who. If Stephen Fry is making fun of me, I might as well kill myself right now.
Some british show contacted me for permission to use a picture for them to make fun of
Is it a picture of you? That's really the only thing that would be offensive is if they say "Hey, look at this chick. What's the matter with her?". Or are they trying to make fun of your photography?