i am thrilled about the following:
character creation takes you thru the childhood of your character! (the only other time i remember seeing something like this, it was the only good part of an absolutely terrible game, but dang if i didn't like the idea)
monsters DO NOT LEVEL WITH YOUR CHARACTER (thank GOD bethesda realized this is a bad fucking idea, i did not want f3 to have this
)
V.A.T.S, V.A.T.S,
V.A.T.S 
i fucking love the way this merges real-time and turn-based, but of course having not seen it in action i don't know FOR SURE if it's gonna work how i'm imagining, but if it does, holy shit awesome :o
not only is it gonna be gory but it's gonna have SLOW-MOTION GORE
hahaha a portable nuke launcher
more specific injuries in addition to HP, just like the last two
and everything, especially ron perlman, in the trailer
good NIGHT
Hybrid Mode
