you said lasting power, if the main character dropped his life as high school teacher to be a meth cooker because he was diagnosed with cancer, I think naturally the stories gonna come to the point where he's eventually going to die.
this is analogous to prison break where the show revolves around breaking out of a prison, which can only take so much time so the story becomes convoluted and they break out of prisons all across the world like a disney on ice tour.
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